CTE typeI tau filament from Guam ALS/PDC
Resolution: 2.0 Å
EM Method: Helical reconstruction
Fitted PDBs: 8ot6
Q-score: 0.709
Qi C, Verheijen BM, Kokubo Y, Shi Y, Tetter S, Murzin AG, Nakahara A, Morimoto S, Vermulst M, Sasaki R, Aronica E, Hirokawa Y, Oyanagi K, Kakita A, Ryskeldi-Falcon B, Yoshida M, Hasegawa M, Scheres SHW, Goedert M
PNAS (2023) 120 pp. e2306767120-e2306767120 [ Pubmed: 38100415 DOI: doi:10.1073/pnas.2306767120 ]
- Microtubule-associated protein tau (45 kDa, Protein from Homo sapiens)
- Tau filaments from guam als/pdc (Complex from Homo sapiens)
CTE typeIII tau filament from Guam ALS/PDC
Resolution: 3.4 Å
EM Method: Helical reconstruction
Fitted PDBs: 8ot9
Q-score: 0.551
Qi C, Verheijen BM, Kokubo Y, Shi Y, Tetter S, Murzin AG, Nakahara A, Morimoto S, Vermulst M, Sasaki R, Aronica E, Hirokawa Y, Oyanagi K, Kakita A, Ryskeldi-Falcon B, Yoshida M, Hasegawa M, Scheres SHW, Goedert M
PNAS (2023) 120 pp. e2306767120-e2306767120 [ Pubmed: 38100415 DOI: doi:10.1073/pnas.2306767120 ]
- Microtubule-associated protein tau (45 kDa, Protein from Homo sapiens)
- Tau filaments from guam als/pdc (Complex from Homo sapiens)
CTE typeII tau filament from Guam ALS/PDC
Resolution: 3.2 Å
EM Method: Helical reconstruction
Fitted PDBs: 8otc
Q-score: 0.481
Qi C, Verheijen BM, Kokubo Y, Shi Y, Tetter S, Murzin AG, Nakahara A, Morimoto S, Vermulst M, Sasaki R, Aronica E, Hirokawa Y, Oyanagi K, Kakita A, Ryskeldi-Falcon B, Yoshida M, Hasegawa M, Scheres SHW, Goedert M
PNAS (2023) 120 pp. e2306767120-e2306767120 [ Pubmed: 38100415 DOI: doi:10.1073/pnas.2306767120 ]
- Microtubule-associated protein tau (45 kDa, Protein from Homo sapiens)
- Tau filaments from guam als/pdc (Complex from Homo sapiens)
CTE typeI tau filament from Kii ALS/PDC
Resolution: 2.1 Å
EM Method: Helical reconstruction
Fitted PDBs: 8otg
Q-score: 0.681
Qi C, Verheijen BM, Kokubo Y, Shi Y, Tetter S, Murzin AG, Nakahara A, Morimoto S, Vermulst M, Sasaki R, Aronica E, Hirokawa Y, Oyanagi K, Kakita A, Ryskeldi-Falcon B, Yoshida M, Hasegawa M, Scheres SHW, Goedert M
PNAS (2023) 120 pp. e2306767120-e2306767120 [ Pubmed: 38100415 DOI: doi:10.1073/pnas.2306767120 ]
- Microtubule-associated protein tau (45 kDa, Protein from Homo sapiens)
- Typei tau filaments from kii als/pdc (Complex from Homo sapiens)
TypeII tau filament from Kii ALS/PDC
Resolution: 3.4 Å
EM Method: Helical reconstruction
Fitted PDBs: 8oth
Q-score: 0.512
Qi C, Verheijen BM, Kokubo Y, Shi Y, Tetter S, Murzin AG, Nakahara A, Morimoto S, Vermulst M, Sasaki R, Aronica E, Hirokawa Y, Oyanagi K, Kakita A, Ryskeldi-Falcon B, Yoshida M, Hasegawa M, Scheres SHW, Goedert M
PNAS (2023) 120 pp. e2306767120-e2306767120 [ Pubmed: 38100415 DOI: doi:10.1073/pnas.2306767120 ]
Resolution: 2.7 Å
EM Method: Helical reconstruction
Fitted PDBs: 8oti
Q-score: 0.619
Qi C, Verheijen BM, Kokubo Y, Shi Y, Tetter S, Murzin AG, Nakahara A, Morimoto S, Vermulst M, Sasaki R, Aronica E, Hirokawa Y, Oyanagi K, Kakita A, Ryskeldi-Falcon B, Yoshida M, Hasegawa M, Scheres SHW, Goedert M
PNAS (2023) 120 pp. e2306767120-e2306767120 [ Pubmed: 38100415 DOI: doi:10.1073/pnas.2306767120 ]
- Cte typeiii tau filaments (Complex from Homo sapiens)
- Microtubule-associated protein tau (45 kDa, Protein from Homo sapiens)
PHF tau filament from Kii ALS/PDC
Resolution: 3.3 Å
EM Method: Helical reconstruction
Fitted PDBs: 8otj
Q-score: 0.521
Qi C, Verheijen BM, Kokubo Y, Shi Y, Tetter S, Murzin AG, Nakahara A, Morimoto S, Vermulst M, Sasaki R, Aronica E, Hirokawa Y, Oyanagi K, Kakita A, Ryskeldi-Falcon B, Yoshida M, Hasegawa M, Scheres SHW, Goedert M
PNAS (2023) 120 pp. e2306767120-e2306767120 [ Pubmed: 38100415 DOI: doi:10.1073/pnas.2306767120 ]
- Phf tau filaments from kii als/pdc (Complex from Homo sapiens)
- Microtubule-associated protein tau (45 kDa, Protein from Homo sapiens)
CTE type II (tau intermediate amyloid)
Resolution: 3.35 Å
EM Method: Helical reconstruction
Fitted PDBs: 8qjj
Q-score: 0.484
Lovestam S, Li D, Wagstaff JL, Kotecha A, Kimanius D, McLaughlin SH, Murzin AG, Freund SMV, Goedert M, Scheres SHW
Nature (2024) 625 pp. 119-125 [ DOI: doi:10.1038/s41586-023-06788-w Pubmed: 38030728 ]
- Amyloid (Complex from Homo sapiens)
- Isoform tau-d of microtubule-associated protein tau (40 kDa, Protein from Homo sapiens)
P301S Tau Filaments from the Brains of PS19 Transgenic Mouse Line
Resolution: 3.05 Å
EM Method: Helical reconstruction
Fitted PDBs: 8q92
Q-score: 0.556
Schweighauser M, Murzin AG, Macdonald J, Lavenir I, Crowther RA, Scheres SHW, Goedert M
Acta Neuropathol (2023) 11 pp. 160-160 [ Pubmed: 37798679 DOI: doi:10.1186/s40478-023-01658-y ]
- Microtubule-associated protein tau (9 kDa, Protein from Homo sapiens)
- P301s tau protein filament (ps19) (Tissue from Mus musculus)
P301S Tau Filaments from the Brains of Tg2541 Transgenic Mouse Line
Resolution: 3.09 Å
EM Method: Helical reconstruction
Fitted PDBs: 8q96
Q-score: 0.592
Schweighauser M, Murzin AG, Macdonald J, Lavenir I, Crowther RA, Scheres SHW, Goedert M
Acta Neuropathol (2023) 11 pp. 160-160 [ Pubmed: 37798679 DOI: doi:10.1186/s40478-023-01658-y ]
- Unknown protein (1 kDa, Protein from Mus musculus)
- Isoform tau-e of microtubule-associated protein tau (5 kDa, Protein from Mus musculus)
- P301s tau protein filament (tg2541) (Tissue from Mus musculus)
- Unknown protein (869 Da, Protein from Mus musculus)